1-MethylpseudoUridine

1-MethylpseudoUridine - CAS 13860-38-3

N1-methyl-pseudoUridine (1-Methylpseudouridine), a methylpseudoUridine, outperforms 5 mC and 5 mC/N1-methyl-pseudoUridine in translation. N1-methyl-pseudoUridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density.

Catalog Number
B2706-207673
CAS
13860-38-3
Molecular Weight
258.23
Molecular Formula
C10H14N2O6
Symbol
m1Ψ
Synonyms
N1-Methylpseudouridine; 2,4(1H,3H)-Pyrimidinedione, 1-methyl-5-b-D-ribofuranosyl-; (-)-1-Methyl-5-(β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione; Antibiotic U-50228; U-50228; 1-N-Me-pseudouridine; (1S)-1,4-anhydro-1-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol; Uracil, 1-methyl-5-b-D-ribofuranosyl-
IUPAC Name
5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methylpyrimidine-2,4-dione
Canonical SMILES
CN1C=C(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
InChI
InChI=1S/C10H14N2O6/c1-12-2-4(9(16)11-10(12)17)8-7(15)6(14)5(3-13)18-8/h2,5-8,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,8+/m1/s1
InChIKey
UVBYMVOUBXYSFV-XUTVFYLZSA-N
Purity
≥95%
Density
1.6±0.1 g/cm3
Appearance
White to pale pink powder
Storage
Storage at 2-8°C
Symbol
m1Ψ

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