5-((6aR,8S,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione-3-15N

5-((6aR,8S,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione-3-15N

Molecular Weight
515.76
Molecular Formula
C23H42[15N]NO7Si2
Synonyms
5-((6aR,8S,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione-3-15N
1. Synthesis of 15N-Enriched Pseudouridine Derivatives.
Desaulniers, J. P., Ksebati, B., & Chow, C. S. (2003). Organic Letters, 5(22), 4093-4096.
A procedure for the chemical synthesis of [3-15N]-labeled pseudouridine and a methylated derivative was developed. A suitably protected pseudouridine precursor was nitrated at N3 followed by treatment with 15NH4Cl to afford the 15N-labeled product in six steps with a 20% yield. This methodology will allow for the production of RNAs with [3-15N]pseudouridine and [3-15N-methyl]pseudouridine at specific locations.

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