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5-((6aR,8S,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione-3-15N
Molecular Weight
515.76
Molecular Formula
C23H42[15N]NO7Si2
Synonyms
5-((6aR,8S,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione-3-15N
1. Synthesis of 15N-Enriched Pseudouridine Derivatives.
Desaulniers, J. P., Ksebati, B., & Chow, C. S. (2003). Organic Letters, 5(22), 4093-4096.
A procedure for the chemical synthesis of [3-15N]-labeled pseudouridine and a methylated derivative was developed. A suitably protected pseudouridine precursor was nitrated at N3 followed by treatment with 15NH4Cl to afford the 15N-labeled product in six steps with a 20% yield. This methodology will allow for the production of RNAs with [3-15N]pseudouridine and [3-15N-methyl]pseudouridine at specific locations.
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Chemical Structure
![5-((6aR,8S,9R,9aR)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione-3-15N](https://resource.bocsci.com/structure/5-%28%286ar%2C8s%2C9r%2C9ar%29-9-hydroxy-2%2C2%2C4%2C4-tetraisopropyltetrahydro-6h-furo%5B3%2C2-f%5D%5B1%2C3%2C5%2C2%2C4%5Dtrioxadisilocin-8-yl%29-1%2C3-dimethylpyrimidine-2%2C4%281h%2C3h%29-dione-3-15n.gif)
