N1-MethylpseudoUridine-5'-Triphosphate

N1-MethylpseudoUridine-5'-Triphosphate - CAS 1428903-59-6

N1-MethylpseudoUridine-5'-Triphosphate is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-methylpseudouridine can reduce the immunogenicity of the resulting mRNA. The sodium form N1-MethylpseudoUridine-5'-Triphosphate Sodium (B2706-358101) is in stock.

Catalog Number
1428903-59-6
CAS
1428903-59-6
Molecular Weight
498.17
Molecular Formula
C10H17N2O15P3
Synonyms
1-Methylpseudouridine-5'-Triphosphate; N1-Methylpseudo-UTP; 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-1-methyl-; 1-Methylpseudo-UTP
IUPAC Name
[[(2R,3S,4R,5S)-3,4-dihydroxy-5-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Canonical SMILES
CN1C=C(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
InChI
InChI=1S/C10H17N2O15P3/c1-12-2-4(9(15)11-10(12)16)8-7(14)6(13)5(25-8)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-8,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t5-,6-,7-,8+/m1/s1
InChIKey
OLRONOIBERDKRE-XUTVFYLZSA-N
Purity
≥95%
Density
2.010±0.06 g/cm3 (Predicted)
Appearance
Clear colourless solution
Storage
Storage at -20°C

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